Printed in Basel in 1543, Andreas Vesalius' De Humani Corporis Fabrica is considered to be the first "modern" medical book that emphasizes clinical observation over a dependence on ancient texts. The Library of Congress has recently digitized its copy of De Fabrica, which was part of the generous gift of Lessing J. Rosenwald to the nation.
The Library of Congress has several important works by the printmaker, painter, and art theorist, Albrecht Dürer (1471-1528), including his famous engraving, Melencolia I (1514), and his Treatise on Measurement (1525).
Gregor Reisch's (c.1470-1525) encyclopedic textbook, Margarita Philosophica (Philosophical Pearl) contains a woodcut that speaks to the process of education in the sixteenth century.